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Introducing the TIME‑ZZZ Translational Initiative to Map Epigenetics in Sleep (TIME-ZZZ)
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Calling all
Index users! Join us in a groundbreaking study that aims to advance our understanding of the associations between chronotype, sleep quality, mental health, and biological aging: TIME-ZZZ. This new Elysium longevity study focused on sleep is now enrolling—and all Index users are eligible to participate.
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What is the relationship between sleep and circadian rhythm disruption and biological aging? Does it increase your risk of depression? What are the epigenetic signatures of sleep and circadian rhythm disruption? With your participation, we’ll answer these questions in TIME-ZZZ.
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We’re honored to partner with renowned sleep expert
Russell Foster, Ph.D., principal investigator of TIME-ZZZ. Dr. Foster serves as Professor of Circadian Neuroscience and Head of the Department of Ophthalmology at the University of Oxford, and is a member of the Elysium Scientific Advisory Board. He’s joined by fellow principal investigator
Dayle Sampson, Ph.D., Elysium’s vice president of bioinformatics. Don't miss this chance to be among the first participants contributing to a better understanding of the relationship between sleep and longevity.
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“It seems that
sleep and
circadian
rhythm
disruption (SCRD) is an important risk factor for biological aging, but we do not understand the mechanisms. The TIME-ZZZ study will address this deficit in our knowledge. [...] Such fundamental knowledge will provide a key platform for the development of novel, evidence-based and condition specific therapeutic agents.”
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Get your signed copy of
Life Time, by sleep expert Russell Foster, Ph.D.
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The clock is ticking to get your copy of the
Sunday Times bestseller,
Life Time, signed by the author Russell Foster, Ph.D. With enrollment in TIME-ZZZ picking up steam, we only have a few books remaining for the next Index users who
enroll in TIME-ZZZ and complete the questionnaires. Enroll today to get a piece of sleep science history. In
Life Time, Dr. Foster makes the complex science of our body clock (or circadian rhythms) accessible, drawing on scientific research including decades of his own work in visual and circadian neurobiology. Readers learn the importance of our circadian rhythms, how contemporary life can disrupt them, and how to get back in sync to be healthier and more robust.
“If you want to embrace life,” he writes,
“then embracing biological time will help you do this.”
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Take a glimpse into the fascinating science behind the body clock in the video synopsis of
Life Time (produced by Penguin) in the video link below.
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Join an exclusive sleep science webinar with Russell Foster, Ph.D.
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We’re pleased to announce a very special webinar with Dr. Foster:
Sleep, Circadian Rhythms and Health: Looking Forward to Healthy Aging. Our bodies require very intricate molecular and cellular coordination to function optimally—the correct materials, delivered to the correct tissues and organs, in the right concentration, at the appropriate time of day. This structure is provided by our body clock, and without it our biological systems break down, impacting growth, metabolism, memory formation, immune function, and more. As we age our circadian drive becomes less robust. In this short presentation, Dr. Foster will outline what we know and, more importantly, what we do not know about the impact of age on our circadian and sleep biology.
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All members of the Elysium community (that’s you!) are invited to join the webinar, which will take place on
Tuesday, July 16th at 11 a.m. - 12 p.m. EST. Register using the link below.
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Chronotypes of the Elysium Scientific Advisory Board—how do you compare?
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Do you know your chronotype? This is the time of day your body naturally wants to wake up and go to sleep—and it’s dictated by genetics, age, and when we see light. Whether you’re a lark (early to bed, up early), a night owl (late to bed, up late), or a dove (somewhere in-between), knowing your natural rhythm can help you optimize your wakefulness and rest. Being “out of phase” with your chronotype means there is a mismatch between your circadian rhythm and imposed social schedule, resulting in social jet lag, which can impact how you function and even increase the risk of diverse pathologies.
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We surveyed the esteemed members of our
Scientific Advisory Board with the ultrashort Munich ChronoType Questionnaire (µMCTQ), a 4-question self-report measure designed to assess an individual's chronotype and degree of social jet lag. Surprisingly, there were no “late” chronotypes among the 11 surveyed members. They skewed “early” (average wake times ranging from 5:00 to 6:45 a.m.) to “intermediate” (average wake time of 7:30 a.m.). In comparison, 41% of the general population exhibit a “late” chronotype, while 30% fall into the “intermediate” and 29% into the “early” category. The majority of those surveyed demonstrated no social jet lag, suggesting their social schedules are well-aligned to their chronotypes.
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Curious how you compare?
Index users who enroll in TIME-ZZZ will receive their chronotype, social jet lag, and how they stack up to the general population.
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Sleep tips from the Elysium
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Scientific Advisory Board
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Sleep tips from the Elysium
Scientific Advisory Board
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How do some of the world’s top scientists and clinicians (including four Nobel laureates) approach sleep? We asked members of our
Scientific Advisory Board to tell us their tips and what they’re willing to give up for a predictable night of sleep. Answers are ranked from most common (at the top) to least common (at the bottom).
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What are your tips for a great night’s sleep?
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Regular exercise (but not late in the day)
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Keep sleep schedule consistent
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Blackout shades or dark bedroom
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Calm thoughts before bed or meditation
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Small amount of alcohol before bed
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Reduce blue light from screens in the PM
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“I only drink coffee in the morning. I feel like I sleep better on days when I walk a lot (10-15K steps). Doing the NYT word puzzles, especially Spelling Bee, knocks me out every time!”
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Jack Szostak, Ph.D.
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Is there anything worth sacrificing a good night's sleep for?
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Concerts, celebrations, and sporting events
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AGING 101
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What’s your chronotype? Find out what your unique sleep personality reveals about you and your health
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Chronotype is your body's natural preference for sleep and wakeful times. Learn how to determine your chronotype and use it to your advantage. (Read more)
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